Journal article
Tuning drug dosing through matching optically active polymer composition and NIR stimulation parameters
SW Gietman, SM Silva, B del Rosal, RMI Kapsa, PR Stoddart, SE Moulton
International Journal of Pharmaceutics | ELSEVIER | Published : 2020
Abstract
Controlled release is at the forefront of modern bioscience as it aims to address challenges associated with the dosing of drugs within required levels for therapeutic effect. Many materials and approaches can be used to control the release from different reservoirs including nanoparticles, liposomes and hydrogels. Using thermoresponsive hydrogels, near infrared illumination of plasmonic nanoparticles can be used to control the hydrogel through localised surface plasmon resonance heating. This work extends beyond a material level and pursues detailed examination of the drug release characteristics of a variable acrylic acid poly(N-isopropylacrylamide) coated gold nanorod system using dexamet..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by Swinburne University of Technology, the ARC Centre of Excellence for Electromaterials Science (ACES) [CE140100012], the ARC Training Centre in Biodevices [IC140100023] and the Australian Research Council Centre of Excellence Scheme. The authors would like to acknowledge Professor Sally McArthur for her contributions and discussions around this work. The authors further acknowledge the facilities, the scientific and technical assistance of the Fluorescence Imaging Group, Departamento de Fisica de Materiales, Universidad Autonoma de Madrid and thank Lucia Labrador for the thermal calibration of the quantum dots employed in the luminescence thermometry experiments.